loadIntActFTP.RdloadIntActFTP loads all data stored on ftp://ftp.ebi.ac.uk/pub/databases/intact/current/psimitab/ in intact.txt file. Details: https://www.ebi.ac.uk/intact/downloads. This file contains the data from the following databases "IntAct", "MINT", "DIP", "bhf-ucl", "MPIDB", "MatrixDB", "HPIDb","I2D-IMEx","InnateDB-IMEx", "MolCon", "UniProt", "MBInfo"
loadIntActFTP(dir, release = NULL)
| dir | directory where to save/look for the local copy |
|---|---|
| release | which locally saved IntAct release to load (the default is to load the latest and read it into R) |
loadIntActFTP saves intact.txt to a file, returns the object of class RAW_MItab27
{ loadIntActFTP("./", release = NULL) }#>#>#> Warning: Found and resolved improper quoting out-of-sample. First healed line 25383: <<uniprotkb:P16054 uniprotkb:Q05769 intact:EBI-298451 intact:EBI-298933|uniprotkb:Q543K3 psi-mi:kpce_mouse(display_long)|uniprotkb:Prkce(gene name)|psi-mi:Prkce(display_short)|uniprotkb:Pkce(gene name synonym)|uniprotkb:Pkcea(gene name synonym)|uniprotkb:nPKC-epsilon(gene name synonym) psi-mi:pgh2_mouse(display_long)|uniprotkb:Ptgs2(gene name)|psi-mi:Ptgs2(display_short)|uniprotkb:Cox-2(gene name synonym)|uniprotkb:Cox2(gene name synonym)|uniprotkb:Pghs-b(gene name synonym)|uniprotkb:Tis10(gene na>>. If the fields are not quoted (e.g. field separator does not appear within any field), try quote="" to avoid this warning.#> #> ` Object of class RAW_MItab27, for query, file, format, databases, date: ` #> [1] "This object contains the data from ftp://ftp.ebi.ac.uk/pub/databases/intact/current/psimitab/intact.txt and contains all molecular interaction data from the following databases: \"IntAct\", \"MINT\", \"DIP\", \"bhf-ucl\", \"MPIDB\", \"MatrixDB\", \"HPIDb\",\"I2D-IMEx\",\"InnateDB-IMEx\", \"MolCon\", \"UniProt\", \"MBInfo\"" #> #> ` view of the $data: ` #> #ID(s) interactor A ID(s) interactor B #> 1: uniprotkb:P49418 uniprotkb:O43426 #> 2: uniprotkb:P49418 intact:EBI-7121639 #> 3: uniprotkb:P49418 intact:EBI-7121654 #> 4: uniprotkb:P49418 intact:EBI-7121715 #> 5: intact:EBI-7121765 uniprotkb:P49418 #> --- #> 882958: uniprotkb:P62158 uniprotkb:P19634 #> 882959: uniprotkb:Q96BS2 uniprotkb:P19634 #> 882960: uniprotkb:Q96BS2 uniprotkb:P19634 #> 882961: uniprotkb:Q99714-1 uniprotkb:Q99714-1 #> 882962: intact:EBI-21017293 intact:EBI-21229288 #> Alt. ID(s) interactor A #> 1: intact:EBI-7121510|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 #> 2: intact:EBI-7121510|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 #> 3: intact:EBI-7121510|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 #> 4: intact:EBI-7121510|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 #> 5: intact:MINT-8094691 #> --- #> 882958: intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23 #> 882959: intact:EBI-740653|uniprotkb:Q9NWT9|uniprotkb:F5H1Y5 #> 882960: intact:EBI-740653|uniprotkb:Q9NWT9|uniprotkb:F5H1Y5 #> 882961: intact:EBI-21224398 #> 882962: rnacentral:URS00002075FA_9606 #> Alt. ID(s) interactor B #> 1: intact:EBI-2821539|uniprotkb:O43425|uniprotkb:O94984|uniprotkb:Q4KMR1 #> 2: intact:MINT-8094608 #> 3: intact:MINT-8094645 #> 4: intact:MINT-8094663 #> 5: intact:EBI-7121510|uniprotkb:Q75MK5|uniprotkb:Q75MM3|uniprotkb:A4D1X9|intact:MINT-109264|uniprotkb:O43538|uniprotkb:A4D1X8|uniprotkb:Q75MJ8|uniprotkb:Q8N4G0 #> --- #> 882958: intact:EBI-743635|uniprotkb:Q96EM2|uniprotkb:B1ALD6|uniprotkb:D3DPL4 #> 882959: intact:EBI-743635|uniprotkb:Q96EM2|uniprotkb:B1ALD6|uniprotkb:D3DPL4 #> 882960: intact:EBI-743635|uniprotkb:Q96EM2|uniprotkb:B1ALD6|uniprotkb:D3DPL4 #> 882961: intact:EBI-21224398 #> 882962: ensembl:ENST00000430479.5 #> Alias(es) interactor A #> 1: psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) #> 2: psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) #> 3: psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) #> 4: psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) #> 5: psi-mi:xrprrghal(display_short)|psi-mi:EBI-7121765(display_long) #> --- #> 882958: psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym) #> 882959: psi-mi:chp3_human(display_long)|uniprotkb:TESC(gene name)|psi-mi:TESC(display_short)|uniprotkb:CHP3(gene name synonym)|uniprotkb:Tescalcin(gene name synonym) #> 882960: psi-mi:chp3_human(display_long)|uniprotkb:TESC(gene name)|psi-mi:TESC(display_short)|uniprotkb:CHP3(gene name synonym)|uniprotkb:Tescalcin(gene name synonym) #> 882961: psi-mi:q99714-1(display_long)|uniprotkb:HSD17B10(gene name)|psi-mi:HSD17B10(display_short)|uniprotkb:ERAB(gene name synonym)|uniprotkb:HADH2(gene name synonym)|uniprotkb:MRPP2(gene name synonym)|uniprotkb:SCHAD(gene name synonym)|uniprotkb:SDR5C1(gene name synonym)|uniprotkb:XH98G2(gene name synonym) #> 882962: psi-mi:hsa-mir-17 5p(display_short)|psi-mi:EBI-21017293(display_long) #> Alias(es) interactor B #> 1: psi-mi:synj1_human(display_long)|uniprotkb:SYNJ1(gene name)|psi-mi:SYNJ1(display_short)|uniprotkb:KIAA0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym) #> 2: psi-mi:vrparrvlw(display_short)|psi-mi:EBI-7121639(display_long) #> 3: psi-mi:hrpvrraap(display_short)|psi-mi:EBI-7121654(display_long) #> 4: psi-mi:vrptraada(display_short)|psi-mi:EBI-7121715(display_long) #> 5: psi-mi:amph_human(display_long)|uniprotkb:AMPH(gene name)|psi-mi:AMPH(display_short)|uniprotkb:AMPH1(gene name synonym) #> --- #> 882958: psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym) #> 882959: psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym) #> 882960: psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym) #> 882961: psi-mi:q99714-1(display_long)|uniprotkb:HSD17B10(gene name)|psi-mi:HSD17B10(display_short)|uniprotkb:ERAB(gene name synonym)|uniprotkb:HADH2(gene name synonym)|uniprotkb:MRPP2(gene name synonym)|uniprotkb:SCHAD(gene name synonym)|uniprotkb:SDR5C1(gene name synonym)|uniprotkb:XH98G2(gene name synonym) #> 882962: psi-mi:mrna_etv1(display_short)|psi-mi:EBI-21229288(display_long) #> Interaction detection method(s) #> 1: psi-mi:"MI:0084"(phage display) #> 2: psi-mi:"MI:0084"(phage display) #> 3: psi-mi:"MI:0084"(phage display) #> 4: psi-mi:"MI:0084"(phage display) #> 5: psi-mi:"MI:0084"(phage display) #> --- #> 882958: psi-mi:"MI:0071"(molecular sieving) #> 882959: psi-mi:"MI:0065"(isothermal titration calorimetry) #> 882960: psi-mi:"MI:1247"(microscale thermophoresis) #> 882961: psi-mi:"MI:0114"(x-ray crystallography) #> 882962: psi-mi:"MI:2285"(miRNA interference luciferase reporter assay) #> Publication 1st author(s) Publication Identifier(s) #> 1: Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 #> 2: Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 #> 3: Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 #> 4: Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 #> 5: Cestra et al. (1999) pubmed:10542231|mint:MINT-5211933 #> --- #> 882958: Fuchs et al. (2018) pubmed:30287853|imex:IM-26821 #> 882959: Fuchs et al. (2018) pubmed:30287853|imex:IM-26821 #> 882960: Fuchs et al. (2018) pubmed:30287853|imex:IM-26821 #> 882961: Kissinger et al. (2004) pubmed:15342248 #> 882962: Li et al. (2017) pubmed:29126392|imex:IM-26887 #> Taxid interactor A #> 1: taxid:9606(human)|taxid:9606(Homo sapiens) #> 2: taxid:9606(human)|taxid:9606(Homo sapiens) #> 3: taxid:9606(human)|taxid:9606(Homo sapiens) #> 4: taxid:9606(human)|taxid:9606(Homo sapiens) #> 5: taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") #> --- #> 882958: taxid:9606(human)|taxid:9606(Homo sapiens) #> 882959: taxid:9606(human)|taxid:9606(Homo sapiens) #> 882960: taxid:9606(human)|taxid:9606(Homo sapiens) #> 882961: taxid:9606(human)|taxid:9606(Homo sapiens) #> 882962: taxid:9606(human)|taxid:9606(Homo sapiens) #> Taxid interactor B #> 1: taxid:9606(human)|taxid:9606(Homo sapiens) #> 2: taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") #> 3: taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") #> 4: taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") #> 5: taxid:9606(human)|taxid:9606(Homo sapiens) #> --- #> 882958: taxid:9606(human)|taxid:9606(Homo sapiens) #> 882959: taxid:9606(human)|taxid:9606(Homo sapiens) #> 882960: taxid:9606(human)|taxid:9606(Homo sapiens) #> 882961: taxid:9606(human)|taxid:9606(Homo sapiens) #> 882962: taxid:9606(human)|taxid:9606(Homo sapiens) #> Interaction type(s) Source database(s) #> 1: psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) #> 2: psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) #> 3: psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) #> 4: psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) #> 5: psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) #> --- #> 882958: psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) #> 882959: psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) #> 882960: psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) #> 882961: psi-mi:"MI:0195"(covalent binding) psi-mi:"MI:0465"(DIP) #> 882962: psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) #> Interaction identifier(s) Confidence value(s) #> 1: intact:EBI-7121552|mint:MINT-16056 intact-miscore:0.56 #> 2: intact:EBI-7121634|mint:MINT-8094596 intact-miscore:0.44 #> 3: intact:EBI-7121659|mint:MINT-8094627 intact-miscore:0.44 #> 4: intact:EBI-7121710|mint:MINT-8094651 intact-miscore:0.44 #> 5: intact:EBI-7121760|mint:MINT-8094677 intact-miscore:0.44 #> --- #> 882958: intact:EBI-21222718|imex:IM-26821-3 intact-miscore:0.44 #> 882959: intact:EBI-21222819|imex:IM-26821-5 intact-miscore:0.62 #> 882960: intact:EBI-21257572|imex:IM-26821-6 intact-miscore:0.62 #> 882961: intact:EBI-21224396|wwpdb:1U7T intact-miscore:0.44 #> 882962: intact:EBI-21229305|imex:IM-26887-1 intact-miscore:0.23 #> Expansion method(s) Biological role(s) interactor A #> 1: - psi-mi:"MI:0499"(unspecified role) #> 2: - psi-mi:"MI:0499"(unspecified role) #> 3: - psi-mi:"MI:0499"(unspecified role) #> 4: - psi-mi:"MI:0499"(unspecified role) #> 5: - psi-mi:"MI:0499"(unspecified role) #> --- #> 882958: - psi-mi:"MI:0499"(unspecified role) #> 882959: - psi-mi:"MI:0499"(unspecified role) #> 882960: - psi-mi:"MI:0499"(unspecified role) #> 882961: - psi-mi:"MI:0499"(unspecified role) #> 882962: - psi-mi:"MI:2274"(regulator) #> Biological role(s) interactor B Experimental role(s) interactor A #> 1: psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) #> 2: psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) #> 3: psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) #> 4: psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) #> 5: psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) #> --- #> 882958: psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) #> 882959: psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) #> 882960: psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) #> 882961: psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) #> 882962: psi-mi:"MI:2275"(regulator target) psi-mi:"MI:0497"(neutral component) #> Experimental role(s) interactor B Type(s) interactor A #> 1: psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) #> 2: psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) #> 3: psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) #> 4: psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) #> 5: psi-mi:"MI:0498"(prey) psi-mi:"MI:0327"(peptide) #> --- #> 882958: psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) #> 882959: psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) #> 882960: psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) #> 882961: psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) #> 882962: psi-mi:"MI:0497"(neutral component) psi-mi:"MI:2204"(micro rna) #> Type(s) interactor B #> 1: psi-mi:"MI:0326"(protein) #> 2: psi-mi:"MI:0327"(peptide) #> 3: psi-mi:"MI:0327"(peptide) #> 4: psi-mi:"MI:0327"(peptide) #> 5: psi-mi:"MI:0326"(protein) #> --- #> 882958: psi-mi:"MI:0326"(protein) #> 882959: psi-mi:"MI:0326"(protein) #> 882960: psi-mi:"MI:0326"(protein) #> 882961: psi-mi:"MI:0326"(protein) #> 882962: psi-mi:"MI:0324"(messenger rna) #> Xref(s) interactor A #> 1: go:"GO:0005543"(phospholipid binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0015629"(actin cytoskeleton)|refseq:NP_001626.1|interpro:IPR003005(Amphiphysin)|rcsb pdb:4ATM|go:"GO:0007268"(chemical synaptic transmission)|interpro:IPR003017(Amphiphysin, isoform 1)|refseq:NP_647477.1|rcsb pdb:3SOG|rcsb pdb:1UTC|interpro:IPR001452(Src homology-3)|rcsb pdb:1KY7|interpro:IPR004148(BAR)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0006897"(endocytosis)|go:"GO:0030054"(cell junction)|interpro:IPR027267|reactome:R-HSA-8856828|ensembl:ENST00000325590|ensembl:ENST00000356264|ensembl:ENSG00000078053|ensembl:ENSP00000317441|ensembl:ENSP00000348602|mint:P49418|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0005829"(cytosol)|go:"GO:0061024"(membrane organization)|rcsb pdb:5M61|rcsb pdb:5M5S|dip:DIP-40729N|interpro:IPR035470|interpro:IPR036028|go:"GO:0005886"(plasma membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|mint:MINT-376294(identity) #> 2: go:"GO:0005543"(phospholipid binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0015629"(actin cytoskeleton)|refseq:NP_001626.1|interpro:IPR003005(Amphiphysin)|rcsb pdb:4ATM|go:"GO:0007268"(chemical synaptic transmission)|interpro:IPR003017(Amphiphysin, isoform 1)|refseq:NP_647477.1|rcsb pdb:3SOG|rcsb pdb:1UTC|interpro:IPR001452(Src homology-3)|rcsb pdb:1KY7|interpro:IPR004148(BAR)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0006897"(endocytosis)|go:"GO:0030054"(cell junction)|interpro:IPR027267|reactome:R-HSA-8856828|ensembl:ENST00000325590|ensembl:ENST00000356264|ensembl:ENSG00000078053|ensembl:ENSP00000317441|ensembl:ENSP00000348602|mint:P49418|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0005829"(cytosol)|go:"GO:0061024"(membrane organization)|rcsb pdb:5M61|rcsb pdb:5M5S|dip:DIP-40729N|interpro:IPR035470|interpro:IPR036028|go:"GO:0005886"(plasma membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|mint:MINT-8094601(identity) #> 3: go:"GO:0005543"(phospholipid binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0015629"(actin cytoskeleton)|refseq:NP_001626.1|interpro:IPR003005(Amphiphysin)|rcsb pdb:4ATM|go:"GO:0007268"(chemical synaptic transmission)|interpro:IPR003017(Amphiphysin, isoform 1)|refseq:NP_647477.1|rcsb pdb:3SOG|rcsb pdb:1UTC|interpro:IPR001452(Src homology-3)|rcsb pdb:1KY7|interpro:IPR004148(BAR)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0006897"(endocytosis)|go:"GO:0030054"(cell junction)|interpro:IPR027267|reactome:R-HSA-8856828|ensembl:ENST00000325590|ensembl:ENST00000356264|ensembl:ENSG00000078053|ensembl:ENSP00000317441|ensembl:ENSP00000348602|mint:P49418|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0005829"(cytosol)|go:"GO:0061024"(membrane organization)|rcsb pdb:5M61|rcsb pdb:5M5S|dip:DIP-40729N|interpro:IPR035470|interpro:IPR036028|go:"GO:0005886"(plasma membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|mint:MINT-8094629(identity) #> 4: go:"GO:0005543"(phospholipid binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0015629"(actin cytoskeleton)|refseq:NP_001626.1|interpro:IPR003005(Amphiphysin)|rcsb pdb:4ATM|go:"GO:0007268"(chemical synaptic transmission)|interpro:IPR003017(Amphiphysin, isoform 1)|refseq:NP_647477.1|rcsb pdb:3SOG|rcsb pdb:1UTC|interpro:IPR001452(Src homology-3)|rcsb pdb:1KY7|interpro:IPR004148(BAR)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0006897"(endocytosis)|go:"GO:0030054"(cell junction)|interpro:IPR027267|reactome:R-HSA-8856828|ensembl:ENST00000325590|ensembl:ENST00000356264|ensembl:ENSG00000078053|ensembl:ENSP00000317441|ensembl:ENSP00000348602|mint:P49418|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0005829"(cytosol)|go:"GO:0061024"(membrane organization)|rcsb pdb:5M61|rcsb pdb:5M5S|dip:DIP-40729N|interpro:IPR035470|interpro:IPR036028|go:"GO:0005886"(plasma membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|mint:MINT-8094653(identity) #> 5: mint:MINT-8094693(identity) #> --- #> 882958: rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:5COC|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|rcsb pdb:2LL7|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(ion channel binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"(Ras guanyl-nucleotide exchange factor activity)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|refseq:NP_001292555.1|rcsb pdb:4OVN|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|rcsb pdb:5DBR|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(cofactor metabolic process)|go:"GO:0075206"(positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process) #> 882959: ensembl:ENST00000335209|ensembl:ENST00000470612|ensembl:ENST00000541210|go:"GO:0005737"(cytoplasm)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|interpro:IPR018247|go:"GO:0005886"(plasma membrane)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|refseq:NP_060369.3|interpro:IPR011992(EF-Hand type)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0050821"(protein stabilization)|go:"GO:0051604"(protein maturation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR002048(Calcium-binding EF-hand)|refseq:NP_001161797.1|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENSG00000088992|ensembl:ENSP00000334785|ensembl:ENSP00000432716|ensembl:ENSP00000445689|go:"GO:0032587"(ruffle membrane)|go:"GO:0008584"(male gonad development)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0005829"(cytosol)|refseq:XP_016875022.1|go:"GO:0015031"(protein transport)|go:"GO:0072659"(protein localization to plasma membrane) #> 882960: ensembl:ENST00000335209|ensembl:ENST00000470612|ensembl:ENST00000541210|go:"GO:0005737"(cytoplasm)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|interpro:IPR018247|go:"GO:0005886"(plasma membrane)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|refseq:NP_060369.3|interpro:IPR011992(EF-Hand type)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0050821"(protein stabilization)|go:"GO:0051604"(protein maturation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR002048(Calcium-binding EF-hand)|refseq:NP_001161797.1|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENSG00000088992|ensembl:ENSP00000334785|ensembl:ENSP00000432716|ensembl:ENSP00000445689|go:"GO:0032587"(ruffle membrane)|go:"GO:0008584"(male gonad development)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0005829"(cytosol)|refseq:XP_016875022.1|go:"GO:0015031"(protein transport)|go:"GO:0072659"(protein localization to plasma membrane) #> 882961: uniprotkb:Q99714-1(isoform-parent)|intact:EBI-21224398(isoform-parent) #> 882962: - #> Xref(s) interactor B #> 1: go:"GO:0007612"(learning)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:0048488"(synaptic vesicle endocytosis)|ensembl:ENST00000357345|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0003723"(RNA binding)|refseq:NP_001153774.1|refseq:NP_001153778.1|refseq:NP_003886.3|refseq:NP_982271.2|ensembl:ENSG00000159082|interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|rcsb pdb:1W80|rcsb pdb:2DNR|rcsb pdb:2VJ0|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0012506"(vesicle membrane)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0097060"(synaptic membrane)|reactome:R-HSA-1660499|reactome:R-HSA-1855183|reactome:R-HSA-1855204|ensembl:ENSP00000349903|go:"GO:0061024"(membrane organization)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0030117"(membrane coat)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0048489"(synaptic vesicle transport)|reactome:R-HSA-8856828|refseq:XP_016883989.1|go:"GO:0098793"(presynapse)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:O43426|interpro:IPR034971|interpro:IPR034972|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR035979|interpro:IPR036691|mint:MINT-376287(identity) #> 2: mint:MINT-8094610(identity) #> 3: mint:MINT-8094647(identity) #> 4: mint:MINT-8094665(identity) #> 5: go:"GO:0005543"(phospholipid binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0015629"(actin cytoskeleton)|refseq:NP_001626.1|interpro:IPR003005(Amphiphysin)|rcsb pdb:4ATM|go:"GO:0007268"(chemical synaptic transmission)|interpro:IPR003017(Amphiphysin, isoform 1)|refseq:NP_647477.1|rcsb pdb:3SOG|rcsb pdb:1UTC|interpro:IPR001452(Src homology-3)|rcsb pdb:1KY7|interpro:IPR004148(BAR)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0006897"(endocytosis)|go:"GO:0030054"(cell junction)|interpro:IPR027267|reactome:R-HSA-8856828|ensembl:ENST00000325590|ensembl:ENST00000356264|ensembl:ENSG00000078053|ensembl:ENSP00000317441|ensembl:ENSP00000348602|mint:P49418|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0005829"(cytosol)|go:"GO:0061024"(membrane organization)|rcsb pdb:5M61|rcsb pdb:5M5S|dip:DIP-40729N|interpro:IPR035470|interpro:IPR036028|go:"GO:0005886"(plasma membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|mint:MINT-8094679(identity) #> --- #> 882958: go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000090020|ensembl:ENSP00000263980|ensembl:ENSP00000363199|go:"GO:0016021"(integral component of membrane)|refseq:NP_003038.2|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|ensembl:ENST00000263980|ensembl:ENST00000374086|go:"GO:0070417"(cellular response to cold)|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2YGG|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070997"(neuron death)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0045121"(membrane raft)|go:"GO:0005737"(cytoplasm)|go:"GO:0006811"(ion transport)|go:"GO:0006885"(regulation of pH)|go:"GO:0010447"(response to acidic pH)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR032103|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014704"(intercalated disc)|go:"GO:0030315"(T-tubule)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:2MDF|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein binding, bridging)|go:"GO:0032947"(protein-containing complex scaffold activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|reactome:R-HSA-2160916|reactome:R-HSA-425986|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005516"(calmodulin binding)|mint:P19634 #> 882959: go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000090020|ensembl:ENSP00000263980|ensembl:ENSP00000363199|go:"GO:0016021"(integral component of membrane)|refseq:NP_003038.2|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|ensembl:ENST00000263980|ensembl:ENST00000374086|go:"GO:0070417"(cellular response to cold)|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2YGG|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070997"(neuron death)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0045121"(membrane raft)|go:"GO:0005737"(cytoplasm)|go:"GO:0006811"(ion transport)|go:"GO:0006885"(regulation of pH)|go:"GO:0010447"(response to acidic pH)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR032103|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014704"(intercalated disc)|go:"GO:0030315"(T-tubule)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:2MDF|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein binding, bridging)|go:"GO:0032947"(protein-containing complex scaffold activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|reactome:R-HSA-2160916|reactome:R-HSA-425986|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005516"(calmodulin binding)|mint:P19634 #> 882960: go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000090020|ensembl:ENSP00000263980|ensembl:ENSP00000363199|go:"GO:0016021"(integral component of membrane)|refseq:NP_003038.2|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|ensembl:ENST00000263980|ensembl:ENST00000374086|go:"GO:0070417"(cellular response to cold)|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2YGG|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070997"(neuron death)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0045121"(membrane raft)|go:"GO:0005737"(cytoplasm)|go:"GO:0006811"(ion transport)|go:"GO:0006885"(regulation of pH)|go:"GO:0010447"(response to acidic pH)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR032103|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014704"(intercalated disc)|go:"GO:0030315"(T-tubule)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:2MDF|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein binding, bridging)|go:"GO:0032947"(protein-containing complex scaffold activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|reactome:R-HSA-2160916|reactome:R-HSA-425986|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005516"(calmodulin binding)|mint:P19634 #> 882961: uniprotkb:Q99714-1(isoform-parent)|intact:EBI-21224398(isoform-parent) #> 882962: refseq:NM_001163148.1(see-also) #> Interaction Xref(s) #> 1: - #> 2: - #> 3: - #> 4: - #> 5: - #> --- #> 882958: - #> 882959: - #> 882960: - #> 882961: - #> 882962: go:"GO:1903231"(mRNA binding involved in posttranscriptional gene silencing) #> Annotation(s) interactor A #> 1: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms|comment:"Stoichiometry: 1.0" #> 2: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms #> 3: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms #> 4: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms #> 5: comment:mint|no-uniprot-update: #> --- #> 882958: comment:"DIP protein P62158 original sequence version: 97"|comment:"DIP protein P62158 original sequence version: 144"|comment:"DIP protein P62158 original sequence version: 146"|comment:"DIP protein P62158 original sequence version: 73"|comment:"DIP protein P62158 original sequence version: 102"|comment:"DIP protein P62158 original sequence version: 98"|comment:"DIP protein P62158 original sequence version: 96"|comment:"DIP protein P62158 original sequence version: 111"|comment:"DIP protein P62158 original sequence version: 131"|comment:"DIP protein P62158 original sequence version: 136"|comment:"DIP protein P62158 original sequence version: 145"|comment:"DIP protein P62158 original sequence version: 154"|comment:"DIP protein P62158 original sequence version: 148"|comment:"DIP protein P62158 original sequence version: 116"|comment:"DIP protein P62158 original sequence version: 120"|comment:"DIP protein P62158 original sequence version: 130" #> 882959: - #> 882960: - #> 882961: - #> 882962: - #> Annotation(s) interactor B #> 1: comment:"Stoichiometry: 1.0" #> 2: comment:mint|no-uniprot-update: #> 3: comment:mint|no-uniprot-update: #> 4: comment:mint|no-uniprot-update: #> 5: function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton|comment:mint|comment:homomint|function:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms #> --- #> 882958: - #> 882959: - #> 882960: - #> 882961: - #> 882962: - #> Interaction annotation(s) #> 1: comment:homomint|comment:domino|comment:mint #> 2: figure legend:F1 F2|comment:domino|comment:mint #> 3: figure legend:F1 F2|comment:domino|comment:mint #> 4: figure legend:F1 F2|comment:domino|comment:mint #> 5: figure legend:F1 F2|comment:domino|comment:mint #> --- #> 882958: figure legend:Figure 2a, 2b|full coverage:Only protein-protein interactions|curation depth:imex curation #> 882959: figure legend:Figure 5, Table S1, Figure S1, Figure S2|full coverage:Only protein-protein interactions|curation depth:imex curation #> 882960: figure legend:Figure 4a, 4b, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation #> 882961: figure legend:Fig 1, Table 1|curation depth:imex curation #> 882962: figure legend:Fig 4 A, B|causality statement:down-regulates quantity by destabilization|full coverage:Only protein-protein interactions|curation depth:imex curation #> Host organism(s) #> 1: taxid:-1(in vitro)|taxid:-1(In vitro) #> 2: taxid:-1(in vitro)|taxid:-1(In vitro) #> 3: taxid:-1(in vitro)|taxid:-1(In vitro) #> 4: taxid:-1(in vitro)|taxid:-1(In vitro) #> 5: taxid:-1(in vitro)|taxid:-1(In vitro) #> --- #> 882958: taxid:-1(in vitro)|taxid:-1(In vitro) #> 882959: taxid:-1(in vitro)|taxid:-1(In vitro) #> 882960: taxid:-1(in vitro)|taxid:-1(In vitro) #> 882961: taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") #> 882962: taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) #> Interaction parameter(s) Creation date Update date #> 1: - 2001/01/10 2014/10/16 #> 2: - 2001/01/10 2014/10/16 #> 3: - 2001/01/10 2014/10/16 #> 4: - 2001/01/10 2014/10/16 #> 5: - 2001/01/10 2014/10/16 #> --- #> 882958: - 2019/02/21 2019/03/13 #> 882959: kd:3.0x10^-9(molar) 2019/02/21 2019/02/22 #> 882960: kd:55.5x10^-9 ~6.8(molar) 2019/02/21 2019/03/13 #> 882961: - 2019/02/26 2019/02/26 #> 882962: - 2019/03/05 2019/03/11 #> Checksum(s) interactor A #> 1: rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 #> 2: rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 #> 3: rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 #> 4: rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 #> 5: rogid:cilZXZ3YLDI1s7n8WNRyUE6EnJQ-2 #> --- #> 882958: rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606 #> 882959: rogid:jGQRRQPEW0Z9Q/EDsPiSnEej/Uk9606 #> 882960: rogid:jGQRRQPEW0Z9Q/EDsPiSnEej/Uk9606 #> 882961: rogid:q6/pRFyay7gQ6bb2rzvKYgfkeaE9606 #> 882962: - #> Checksum(s) interactor B #> 1: rogid:RA73eMbCn6F7MD0ItxF/V7QbjqM9606 #> 2: rogid:lPy6gBhpgvyGSYgOqeHbjcqBtMQ-2 #> 3: rogid:GsDnsVmAo8ZZoKTZ4/uDb2x+h3c-2 #> 4: rogid:M+f6GE3SQXrMBiIVttW1MKhz3M0-2 #> 5: rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 #> --- #> 882958: rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606 #> 882959: rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606 #> 882960: rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606 #> 882961: rogid:q6/pRFyay7gQ6bb2rzvKYgfkeaE9606 #> 882962: - #> Interaction Checksum(s) Negative #> 1: intact-crc:F4234557A3B54840|rigid:n+UcEH4PPLkFnIyvBiXrLefK/xU FALSE #> 2: intact-crc:880913D9000BF26E|rigid:iRObbQsaUeX0PxuKeQwZ73s8iKU FALSE #> 3: intact-crc:B68245E1F0508124|rigid:SlinPP5vIczFOGZjelrO+IXJq1s FALSE #> 4: intact-crc:8F7F46DF027DF34E|rigid:uiWbDe6gaj1XcnJXNxuLLq2l/m4 FALSE #> 5: intact-crc:2EF43A66D9B2D428|rigid:/ki1zA46M4Q+rHcjCcxNhhk+5Xw FALSE #> --- #> 882958: rigid:pmZ1EYf/p1DkkfE0Cdq37aJ461Y FALSE #> 882959: rigid:fa4MD3LE4JjqCnjLZCnaEbdlpJg FALSE #> 882960: rigid:fa4MD3LE4JjqCnjLZCnaEbdlpJg FALSE #> 882961: rigid:CaY72IxKZzYNtksd4eYcXToWVpw FALSE #> 882962: - FALSE #> Feature(s) interactor A #> 1: binding-associated region:626-695(MINT-376295) #> 2: binding-associated region:626-695(MINT-8094602) #> 3: binding-associated region:626-695(MINT-8094630) #> 4: binding-associated region:626-695(MINT-8094654) #> 5: - #> --- #> 882958: his tag:n-n|sufficient binding region:2-149 #> 882959: his tag:n-n|sufficient binding region:2-214 #> 882960: his tag:n-n|sufficient binding region:2-214 #> 882961: mutation:214-214 #> 882962: - #> Feature(s) interactor B #> 1: binding-associated region:1063-1070(MINT-376288) #> 2: - #> 3: - #> 4: - #> 5: binding-associated region:626-695(MINT-8094680) #> --- #> 882958: his tag:c-c|sufficient binding region:633-815|maltose binding protein tag:n-n #> 882959: sufficient binding region:503-545|maltose binding protein tag:n-n #> 882960: sufficient binding region:503-545|maltose binding protein tag:n-n #> 882961: mutation:214-214 #> 882962: mutation decreasing interaction:1885-1892|luciferase tag:0-0 #> Stoichiometry(s) interactor A Stoichiometry(s) interactor B #> 1: - - #> 2: - - #> 3: - - #> 4: - - #> 5: - - #> --- #> 882958: 1 1 #> 882959: - - #> 882960: - - #> 882961: 4 0 #> 882962: - - #> Identification method participant A #> 1: psi-mi:"MI:0078"(nucleotide sequence identification) #> 2: psi-mi:"MI:0078"(nucleotide sequence identification) #> 3: psi-mi:"MI:0078"(nucleotide sequence identification) #> 4: psi-mi:"MI:0078"(nucleotide sequence identification) #> 5: psi-mi:"MI:0083"(peptide synthesis) #> --- #> 882958: psi-mi:"MI:0396"(predetermined participant) #> 882959: psi-mi:"MI:0396"(predetermined participant) #> 882960: psi-mi:"MI:0396"(predetermined participant) #> 882961: psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) #> 882962: psi-mi:"MI:0396"(predetermined participant) #> Identification method participant B #> 1: psi-mi:"MI:0078"(nucleotide sequence identification) #> 2: psi-mi:"MI:0083"(peptide synthesis) #> 3: psi-mi:"MI:0083"(peptide synthesis) #> 4: psi-mi:"MI:0083"(peptide synthesis) #> 5: psi-mi:"MI:0078"(nucleotide sequence identification) #> --- #> 882958: psi-mi:"MI:0396"(predetermined participant) #> 882959: psi-mi:"MI:0396"(predetermined participant) #> 882960: psi-mi:"MI:0396"(predetermined participant) #> 882961: psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) #> 882962: psi-mi:"MI:1220"(tag visualisation by luciferase assay)